The Role of Azelnidipine and Telmisartan in Managing Stage-II Hypertension: A Comprehensive Review

Hypertension, called as high blood pres- sure, occurs when blood flows through the arteries at higher-than-normal pressures. Stage II hypertension is a more severe form of high blood pressure, where the systolic blood pressure is 140mm/Hg, or the dias- tolic blood pressure is 90mm/Hg. For improvement activity of stage II hypertension, Azelnidipine and Telmisartan are newer combination in market, which is effective in stage II Hypertension. Azelnidipine is a Calcium channel blocker, and Telmisartan is an Angi- otensin II receptor blockers. Azlenidipine offers selec- tively inhibiting calcium influx into vascular smooth muscle, leading to vasodilation with minimal reflex tachycardia, while Telmisartan works by blocking the vasoconstrictive effects of angiotensin II, providing additional protection to the cardiovascular system. This review examines the pharmacological profiles, efficacy, safety, and clinical outcomes associated with Azelnidipine and Telmisartan in the treatment of stage II Hypertension. This comprehensive review aims to provide a deeper understanding of the strate- gic use of Azelnidipine and Telmisrtan in the man- agement of stage II Hypertension.