Synthesis and Microbial Activity Determination of Synthesized Products of Iron(II) and Nickel (II) Complexes of Schiff Base Using 2-Aminoaniline and 2-Thiosylaniline

Four Metal complexes of Iron(II) and Nickel(II): FeNcplx, FeScplx, NiNcplx and NiScplx were synthesized in this study. Molar conductivity, elemental composition, color, melting point, and % yield were among the physical and analytical parameters measured for ligands and complexes. Analyzers for FT-IR, UV-VIS, and MS were used for characterization. The FT-IR results indicated the synthetic path rout of the functional groups of the compounds. Deprotonation and the use of phenolic OH in bond formation provide evidence of ligands losing their -OH bond to complexation. There were more peaks in the UV-VIS spectra of 2-aminoaniline complexes and Schiff bases due to the increased number of chromophoric groups. The MS of the results confirmed the proposed structures of the reaction as evident to m/z values indicating molecular weight of the ligands and complexes. The studies of Antibacterial (Salmonella enterica, Escherichia coli, Staphylococcus aureus and Bacillus subtilis) and Antifugal (Aspergillus flavus, Rhizopus stolonifer, Fusarium moniliforme, and Fusarium solani) activities with respect to the synthesized compounds showed that the complexes have greater efficacy in antifungal and antibacterial activities than with the ligands going from the area of inhibition zones. Further research can be done to incorporate these complexed synthesized into antibiotics and other drugs, as evident to antimicrobial efficacy.