An In-Depth Review of Secretome Therapy Approaches in Medical Practice Secretome Therapy in Medicine

In recent years, cell transplantation strategies have shifted focus toward utilizing cell byproducts, particularly the
cell secretome—a collection of proteins and bioactive molecules secreted by cells. Initially defined in the context of bacterial
proteins, the concept of the secretome has expanded to encompass a wide range of biological systems, offering significant
potential in medical applications. Secretome therapy, which leverages the regenerative properties of stem cell-derived factors,
has emerged as a promising approach for tissue repair, disease treatment, and diagnostic innovation. The secretome’s ability
to reduce inflammation, promote tissue repair, and stimulate functional recovery positions it as a versatile tool in modern
medicine. However, the translation of secretome therapy from preclinical studies to clinical practice faces several challenges,
including issues of standardization, scalability, safety, regulatory compliance, and disease-specific optimization. By addressing
these challenges through rigorous research, collaboration, and innovative solutions, secretome therapy can realize its full
potential as a transformative treatment modality. This review underscores the importance of advancing our understanding of
secretome biology and developing effective strategies to harness its therapeutic benefits, ultimately improving patient
outcomes across a spectrum of medical conditions.